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KMID : 0613820190290091023
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Journal of Life Science
2019 Volume.29 No. 9 p.1023 ~ p.1026
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Detection of Estrogen-like Activities of Hydrothermal and Ethanol Extracts of Oriental Medicines
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Lee Dong-Geun
Jo Jung-Kwon
Lee Sang-Hyeon
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Abstract
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The purpose of this study was to investigate the estrogen-like activities of eight oriental medicines, including red ginseng, fenugreek, and dandelion. Hot water and ethanol extracts were prepared from Cervus nippon temminck (Nokgaksang), Cynanchum wilfordii (Baeksuo), Lespedeza cuneata (Yagwanmun), Panax ginseng (red ginseng), Smilax china (Toryeong), Taraxacum platycarpum (Mindeulre, dandelion), Tribulus terresteis (Namgase), and Trigonella foenum-graecum (Horopa, fenugreek). Then, estrogen-like activities were verified by the in vitro transcriptional activity assay. The extracts showing estrogen-like activities were red ginseng, Baeksuo, fenugreek, Yagwanmun, and dandelion in the ethanol extracts, and red ginseng, fenugreek, and Baeksuo in the hydrothermal extracts. Red ginseng extract showed a higher activity than the standard 10-8 M 17β-estradiol in both the hydrothermal and ethanol extract at 500 μg/ml, while the 50 μg/ml of the red ginseng ethanol extract and the 500 μg/ml of the Baeksuo hydrothermal extract showed estradiol activities between 10-9 and 10-8 M 17β-estradiol. This shows that it would be possible to contribute to the development of functional materials using red ginseng, Baeksuo, fenugreek, and dandelion.
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KEYWORD
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Estrogen-like activities, in vitro transcriptional activity, oriental medicine
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